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Enzymatic Systems for Cellulose degradation

Yeda Research & Development Co., Ltd
posted on 08/10/2011

Enhanced hydrolysis of cellulosic biomass for biofuel production. Bacterial and enzymatic conversion of lignocellulosic biomass into fuel ethanol is gaining great attention due to the increasing prices of fossil fuel and enhanced concerns related to carbon dioxide and the greenhouse effect, as well as due to the constant rising costs of edible raw materials used for production of ethanol (e.g., corn and sugarcane). The complex structure of cellulosic materials requires cooperation of many types of carbohydrate active enzymes for degradation. Therefore, enhancing synergy between carbohydrate active enzymes could lead to improved degradation of cellulosic biomass, and thus has a great impact in the field of energy production from such biomass. The present invention consists of bio-engineered cellulosomes that exhibit enhanced (synergistic) hydrolytic activity on plant cell wall cellulosic biomass.

Suggested Uses

  • Conversion of plant cell wall biomass into soluble sugars, in order to produce bioethanol, other biofuels and biochemicals


  • Bio-engineered cellulosomes exhibit synergystic (improved) activity of degradation of natural substrates compared to the combined action of the free wild-type enzymes

Innovation Details

Detailed Description

The invention involves the conversion of enzymes (cellulases and xylanases) from the free mode to the cellulosmal mode by attachment using a recombinant dockerin molecule. The dockerin-bearing enzymes are incorporated into designer cellulosomes by interaction with a matching cohesion-containing chimeric scaffoldin (scaffoldin subunits contain the cohesin modules that incorporate the enzymes into the cellulosome complex via their resident dockerins). This approach has generated over two fold enhancement of synergistic hydrolysis on plant cell wall cellulosic biomass. These results open new possibilities for designing superior enzyme compositions for degradation of complex polysaccharides into simple soluble sugars.

File Number: 1536 

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This innovation currently is not available for online licensing. Please contact Shiraz Kalir at Yeda Research & Development Co., Ltd for more information.

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Principal Investigator:

Bayer Edward A. Bayer Edward A.

Innovations (3)

Case Manager:

Shiraz Kalir Shiraz Kalir

Innovations (56)

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February 11, 2009

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