Innovation

Munc18-1 and -2 double knockdown PC12 cells

University Health Network - Technology Development and Commercialization
posted on 03/12/2012

Available for licensing: Munc 18-1 and Munc 18-2 double knockdown PC12 cells.


Innovation Details
 

Detailed Description

"Munc18-1 binds to syntaxin-1A via two distinct sites referred to as the ‘closed’ conformation and Nterminus binding. The latter has been shown to stimulate SNARE-mediated exocytosis, whereas the former is believed to be inhibitory or dispensable. To precisely define the contributions of each binding mode, we have engineered Munc18-1/-2 double knockdown neurosecretory cells and show that not only syntaxin-1A and -1B but also syntaxin-2 and -3 were significantly reduced as a result of Munc18-1 and - 2 knockdown."

File Number: MD-PC12 


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Yuan Lew Yuan Lew

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