iPS cell lines produced from ALS patients

MARKETS ADDRESSED : Amyotrophic lateral sclerosis ( ALS ) is a neurodegenerative disorder in which motor neuron loss in the spinal cord and motor cortex leads to progressive paralysis and death. Approximately 5,600 people in the U.S. are diagnosed with ALS each year. The incidence of ALS ...

Small Molecule Compounds that Modulate the 20S Proteasome

MARKETS ADDRESSED : Neurodegenerative disorders: A number of major neurodegenerative diseases (e.g. Parkinson’s, Huntington’s and Alzheimer’s Diseases, ALS ) are due to the accumulation of misfolded proteins in neurons. Small molecules that stimulate proteasome gate openi...

Method for rapidly generating highly diverse and efficient shRNA libraries from individual gene targets, multiple cDNAs, or genome-wide EST collections

MARKETS ADDRESSED : RNA interference (RNAi) has provided the basis for the development of powerful gene inactivation research tools for functional genetic studies and therapeutic target identification, and has opened the door to the new class of therapeutic agents based on RNAi. RNAi-based ...

New therapeutic targets for the treatment of asthma and COPD

MARKETS ADDRESSED : Beta 2-adrenergic receptor (B2AR) agonists are sympathomimetic agents that stimulate bronchodilation. Both short-acting and long-acting B2AR agonists have been used for many years in the treatment of asthma and chronic obstructive pulmonary disease ( COPD ). Although B2AR ...

METHODS AND COMPOUNDS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY

MARKETS ADDRESSED : Spinal Muscular Atrophy ( SMA ) is the leading genetic cause of death in infants. This neurodegenerative disease results from diminished levels of the protein Survival of Motor Neuron ( SMN ) in motor neurons and other cell types, such as muscle. Data derived from SMA pa...

Robotnikinin: small molecule inhibitor of sonic hedgehog (shh) signaling in human cells

MARKETS ADDRESSED : Sonic hedgehog (Shh), the most widely characterized of the Hedgehog homologs, is essential for proper embryonic development and plays important roles in many cancers. The discovery of small-molecule modulators of Shh signaling provides an avenue to regulate the activity of...

Small molecule promoters of beta-cell replication

MARKETS ADDRESSED : Diabetes results from a failure of sufficient insulin production by the pancreatic beta cells. The ability to stimulate beta-cell replication and, consequently, insulin secretion capacity, has the potential to reverse the development and to deter the progression of diabete...

FlexVia: A flexible via enabling novel chip designs for memory and optical storage applications

MARKETS ADDRESSED : The technology is broadly applicable in the MEMS / NEMS and semiconductor industry. Chips produced with the flexible via can be used in place of current technology for CMOS digital logic, solid state memory ( DRAM , SRAM , FLASH ), hard disks, optical disks (for dat...

Specific gut-residing bacteria drives autoimmune arthritis via Th17 cells

MARKETS ADDRESSED : This discovery paves the way for new therapies for autoimmune and inflammatory disorders which inhibit pathways induced by commensal bacteria of the GI tract that lead to Th17 differentiation. These therapies may be used to treat autoimmune disorders localized to the gut,...

Improved sensitivity for near-field scanning optical microscopy

MARKETS ADDRESSED : In the near term, the invention serves as a new imaging approach with sub-wavelength resolution and, so far, unseen detection sensitivity. Unlike other near-field probes that compromise the signal intensity to achieve high spatial resolution, the invention enables large op...