Intra-coronary Functional Measurement using an OCT Catheter

Technology: The Bouma/Tearney Laboratory at the Wellman Center for Photomedicine is developing a single device that performs optical coherence tomography (OCT) and measures intra-coronary pressure and flow parameters. The additional pressure and flow parameters allows a clinician to better deter...

C16:1n7-palmitoleate: A novel lipid hormone as a diagnostic and therapeutic tool

MARKETS ADDRESSED: Insulin resistance is the key factor of a collection of metabolic disorders including Type II diabetes, atherosclerosis, fatty liver disease, hypertension and dyslipidemia. The syndrome has reached epidemic levels worldwide, with 115 million individuals in 2004 suffering from m...

Voltage Emergency Prediction: Reducing Voltage Swings in Semiconductor Chips

MARKETS ADDRESSED: The potential market for this technology is manufacturers of semiconductor chips. Power-constrained CMOS designs are making it increasingly difficult for microprocessor designers to cope with power supply noise. As current draw increases and operating voltage decreases, inducti...

Increasing neural regeneration following traumatic injury

MARKETS ADDRESSED: Identifying a functional receptor for a major class of regeneration inhibitors provides new pathways for research into therapeutic approaches to enhance regeneration, and sheds new light on the functions of the PTP family. Therapeutic applications for this mechanism include sp...

Wnt ligands for the development of diagnostics and treatments of CNS and BBB disorders

MARKETS ADDRESSED: Diseases of the brain are the third leading cause of death after heart disease and cancer. The central nervous system (CNS) is protected from general circulation by specialized vasculature, the tightly-sealed blood-brain barrier. Disruption of central nervous system vasculatur...

Platform technology for small molecule modulators of autophagy in cancer, neurodegenerative diseases and pancreatitis

MARKETS ADDRESSED: Dysfunction of autophagy has been directly associated with neurodegeneration, cancer, pancreatitis, and inflammation. Modulation of this pathway, therefore, is a novel therapeutic approach to a wide variety of diseases: • Autophagy activators for the treatment of neurodegen...

Practical secrecy-preserving, verifiably correct and trustworthy auctions

MARKETS ADDRESSED: Auctions and electronic marketplaces have been used to facilitate trillions of dollars in trade in the world economy. However, fraud is a big issue that can plague electronic auctions. Different fraud possibilities include an auctioneer deviating from the rules of an auction, a...

Zero knowledge proofs in large stock trades

MARKETS ADDRESSED: Auctions and electronic marketplaces have been used to facilitate trillions of dollars in trade in the world economy. However, fraud is a big issue that can plague electronic auctions. Different fraud possibilities include an auctioneer deviating from the rules of an auction, a...

Practical, scaleable method of making optically pure unnatural amino acids provide new set of intermediates for research and commercial use

MARKETS ADDRESSED: Alpha-amino acids, besides their role in proteins, are often used to make small molecule pharmaceuticals and organic catalysts. In general, there are practical and scaleable means available to make alpha-amino acids, natural or unnatural, of either enanatiomer, as chiral inter...

Improved performance of copper interconnects

MARKETS ADDRESSED: This invention, together with the invention from Harvard Case 3181, provides a more effective barrier around Cu interconnects which results in a longer living and faster functioning Integrated Circuits (ICs or chips) with lower power usage. Using commercially available precurso...