PAD4 as an anti-cancer drug target and Inhibition of PAD4 with a-amidine or SiRNAs to Inhibit Cancer Cell Growth Through the p53 Pathway

Our work found that PAD4 interacts with p53. PAD4 was recruited to the p53-target gene promoters, and that the inhibition of PAD4 activates the expression of the p53 target gene p21. As the expression of the p53 target genes, such as p21/WAF1/CIP1 etc., is key to the choice between survival and ...

Method for Low Temperature Synthesis of Single Walled Carbon Nanotubes (SWNTs)

The disclosed invention offers a method of synthesis of single wall carbon nanotubes using a chemical vapor deposition ( CVD ) method at low temperature (less than 680 degrees Celsius).

Liquid Gradient Refractive Index (L-GRIN) Lens

The disclosed invention is an ultra-small tunable microlens which provides variable focusing and scanning within a limited space. The invention, the Liquid Gradient Refractive Index (L- GRIN ) lens, makes it possible to achieve both varying focal length and beam direction using a lens that is l...

Cellulose-Mineral Composites for Wound Care and Tissue Scaffolding

The disclosed invention relates to the use of proteins and certain other compounds for binding calcium-containing mineral compounds to cellulose. Specific minerals include calcium phosphates and calcium carbonate. The invention also relates to the use of certain proteins to bind cellulose to pol...

Encapsulation of Aqueous Phase Systems within Microscopic Volumes

The disclosed invention relates to the construction and characterization of synthetic cells that mimic not only the plasma membrane of eukaryotic cells, but also the presence of cytoplasm and internal structures. Operating under the assumption that the macromolecular reactivity, macromolecular c...

Method for the Fabrication of Transparent YAG Materials

The present invention relates to transparent yttrium aluminum garnet ( YAG ) materials. In particular, this invention relates to a method for making green parts made of YAG using tape casting. These green parts are further processed to produce fully dense, transparent YAG parts. These materi...

Biomimetic aggrecan injection for degenerative disc and lower back pain treatment

Drexel’s researchers and physicians have developed a new injectable synthetic material mimicking aggrecan of nucleus pulposus. Injection of this material can be used to restore mechanical properties of degenerated disc and thus alleviate lower back pain. Degenerative disc disease of the ...

Bioactive scaffolds for skin replacement, regenerative medicine and wound healing

Drexel’s biomedical engineers and physicians have developed a novel bioactive scafforld that can be used as an inexpensive, off-the-shelf skin substitute for regenerative medicine and wound healing applications. Non-healing skin wounds inflict nearly 5 million Americans each year, and tr...

Monitor of depth of anesthesia to detect and prevent awareness during general anesthesia

The proposed product is a medical device for evaluation of the depth of anesthesia to detect and avert awareness during surgery under general anesthesia or sedation. The device is based on functional near-infrared (fNIR) technology and relies on optical techniques derived from the physical princ...

LCL Grafts: Innovative Small Caliber Vascular Grafts for Peripheral and Coronary Bypass Procedures

Peripheral arterial and coronary artery diseases are widespread clinical problems, accounting for more than one million vascular graft surgeries each year in the United States for PAD and >300,000 CABG procedures. To date, attempts to develop a small-bore synthetic coronary artery graft (...